Reaktion #363340

Reaktionsgleichung

benzaldehyde

aniline

bezoic acid

1-hexene

toluene

2-aminopyridine

→

heptanophenone

aminopyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwere added to each 500 ml pressure reactor
2. 2
   workup.STIRRINGwith stirring
3. 3
   SonstigeAfter completion of the reaction, gas chromatography

Vorschrift

Under the same reaction procedure and conditions as in Example 1 (benzaldehyde 0.5 mmol, aniline 0.3 mmol, bezoic acid 0.03 mmol, 1-hexene 2.5 mmol, toluene 0.87 mmol), various 2-aminopyridine derivatives 0.1 mmol as shown in the following table 3, were added to each 500 ml pressure reactor. The mixture was stirred at normal temperature for 2-3 minutes and then combined with Rh(PPh3)3Cl 0.01 mmol. While the reactor was stopped with a stopper, the reactants were heated at 130° C. for 1 hour with stirring. After completion of the reaction, gas chromatography was conducted to determine the yields of heptanophenone, products from various aminopyridine derivatives. The results are presented in Table 3, below.

Quelle