Reaktion #362900

Reaktionsgleichung

4-(piperazin-1-yl)-1H-indole

2-(2-iodoethyl)indane

K2CO3

methyl isobutyl ketone

→

title compound

Ausbeute 47.3%

4-[4-[2-(Indan-2-yl)ethyl]piperazin-1-yl]-1H-indole

Ausbeute 47.3%

Lösungsmittel

N-methylpyrrolidone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 3 h
2. 2
   Filtrationfiltered
3. 3
   Einengenconcentrated in vacuo
4. 4
   SonstigeThe residue was purified on silica gel
5. 5
   Wascheneluted with ethyl acetate-heptane (1:2)
6. 6
   Sonstigeto give a crystalline compound, which
7. 7
   Sonstigewas recrystallized (ethyl acetate)

Vorschrift

A mixture of 4-(piperazin-1-yl)-1H-indole (1.5 g), 2-(2-iodoethyl)indane (2.0 g), K2CO3, methyl isobutyl ketone (150 ml), and N-methylpyrrolidone (10 ml) was boiled under reflux for 3 h. The mixture was allowed to cool to room temperature, filtered, and concentrated in vacuo. The residue was purified on silica gel eluted with ethyl acetate-heptane (1:2) to give a crystalline compound, which was recrystallized (ethyl acetate) to give the title compound (1.2 g, 47%).

Quelle