Reaktion #362805
ord-eba7edf4bfcb4c98a137f080bbc9d8a6
Reaktionsgleichung
Edukte
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
In an analogous manner to that described in Example 1, paragraphs (d) and (e), starting from 2-mercaptoisobutyric acid and ethyl 2-benzylacrylate there was obtained (RS)-2-[[2-[(ethoxy)carbonyl]-3-phenylpropyl]sulfonyl]-2-methylpropionyl chloride, reaction of which with 1-methylpiperazine analogously to Example 2, paragraph (a), and subsequent enzymatic hydrolysis analogously to Example 6, paragraph (c), yielded (S)-α-[[[1-methyl-1-[(4-methyl-1-piperazinyl)carbonyl]ethyl]sulfonyl]methyl]hydrocinnamic acid, MS: 396 (M)+, as a colourless solid.