Reaktion #362804

Reaktionsgleichung

(RS)-2-[[2-[(ethoxy)carbonyl]-3-phenylpropyl]sulfonyl]-2-methylpropionyl chloride

thiomorpholine

→

(S)-α-[[[1-methyl-1-[(tetrahydro-4H-1,4-thiazin-4-yl)carbonyl]ethyl]sulfonyl]methyl]hydrocinnamic acid

Reaktionsbedingungen

Vorschrift

In an analogous manner to that described in Example 1, paragraphs (d) and (e), starting from 2-mercaptoisobutyric acid and ethyl 2-benzylacrylate there was obtained (RS)-2-[[2-[(ethoxy)carbonyl]-3-phenylpropyl]sulfonyl]-2-methylpropionyl chloride, reaction of which with thiomorpholine analogously to Example 2, paragraph (a), and subsequent enzymatic hydrolysis analogously to Example 6, paragraph (c), yielded (S)-α-[[[1-methyl-1-[(tetrahydro-4H-1,4-thiazin-4-yl)carbonyl]ethyl]sulfonyl]methyl]hydrocinnamic acid, MS: 399 (M)+, as a colourless solid.

Quelle