Reaktion #3625

Reaktionsgleichung

4,5-dihydro-5-(4-aminobenzoyl)pyrrolo[1,2-a]quinoxaline

2-methylbenzoyl chloride

triethylamine

→

desired product

N-[4-(pyrrolo[1,2-a]quinoxalin-5(4H)-ylcarbonyl)phenyl]-2-methylbenzamide

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture stirred for 5 hours
2. 2
   WaschenThe reaction mixture is washed with water, 1N HCl, NaHCO3, and brine
3. 3
   SonstigeThe reaction mixture is dried with Na2 SO4
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated in vacuo
6. 6
   Sonstigeto give a solid which
7. 7
   Sonstigeis purified by flash chromatography

Vorschrift

To a stirred solution of 1.5 mmol of 2-methylbenzoyl chloride in 10 ml of methylene chloride is added 3 mmol of triethylamine. After stirring for 15 minutes, 1.5 mmol of 4,5-dihydro-5-(4-aminobenzoyl)pyrrolo[1,2-a]quinoxaline is added and the mixture stirred for 5 hours. The reaction mixture is washed with water, 1N HCl, NaHCO3, and brine. The reaction mixture is dried with Na2 SO4, filtered and evaporated in vacuo to give a solid which is purified by flash chromatography to give the desired product as a solid, m.p. 206°-207° C.

Quelle