Reaktion #3624

Reaktionsgleichung

4,5-dihydro-5-(4-nitrobenzoyl)pyrrolo[1,2-a]quinoxaline

hydrazine

→

desired product

4,5-Dihydro-5(4-aminobenzoyl)pyrrolo[1,2-a]quinoxaline

Lösungsmittel

ethyl alcohol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheating
2. 2
   Temperaturunder reflux for 2 hours
3. 3
   FiltrationThe hot reaction mixture is filtered through diatomaceous earth
4. 4
   Waschenthe filter cake washed with hot chloroform
5. 5
   Einengenthe filtrate concentrated in vacuo
6. 6
   SonstigeThe residue is triturated with ethyl acetate
7. 7
   Filtrationthe mixture filtered

Vorschrift

To a solution of 1 mmol of 4,5-dihydro-5-(4-nitrobenzoyl)pyrrolo[1,2-a]quinoxaline in 20 ml of ethyl alcohol is added 0.2 g of 10% Pd/C and 2.5 mmol of hydrazine followed by stirring and heating under reflux for 2 hours. The hot reaction mixture is filtered through diatomaceous earth and the filter cake washed with hot chloroform and the filtrate concentrated in vacuo. The residue is triturated with ethyl acetate and the mixture filtered to give the desired product as crystals, m.p. 225°-228° C.

Quelle