Reaktion #362397

Reaktionsgleichung

1-acetoxy-4-dibenzylamino-2-butene

dicyclohexylmethylamine

→

title compound

N,N-Dicyclohexylmethyl-N',N'-dibenzyl-2-butene-1,4-diamine

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture is concentrated in vacuo to a solid which
2. 2
   workup.DISSOLUTIONis redissolved in 100 ml of THF
3. 3
   workup.ADDITIONtreated with 25 ml of 20% aqueous sodium hydroxide
4. 4
   workup.STIRRINGThe mixture is stirred for one hour
5. 5
   Einengenconcentrated
6. 6
   Extraktionextracted with diethyl ether
7. 7
   TrocknenThe ether extracts are dried
8. 8
   Einengenconcentrated
9. 9
   Sonstigeto give a solid which
10. 10
    Sonstigeis then purified by crystallization from isopropanol

Vorschrift

A solution of 1-acetoxy-4-dibenzylamino-2-butene (10.1 g, 33 mmol) and dicyclohexylmethylamine (6.8 g, 32 mmol) in 50 ml of THF is treated with tetrakis(triphenylphosphine)palladium(0) (1.0 g, 0.9 mmol) and stirred at room temperature overnight. The reaction mixture is concentrated in vacuo to a solid which is redissolved in 100 ml of THF and treated with 25 ml of 20% aqueous sodium hydroxide. The mixture is stirred for one hour, concentrated and extracted with diethyl ether. The ether extracts are dried and concentrated to give a solid which is then purified by crystallization from isopropanol. The title compound is obtained in a yield of 9.7 g (65%) as a white solid melting at 61°-62° C.

Quelle