Reaktion #3623

Reaktionsgleichung

4,5-dihydro-5-(4-nitrobenzoyl)pyrrolo[1,2-a]quinoxaline

ethyl acetate

→

desired product

4,5-Dihydro-5(4-aminobenzoyl)pyrrolo[1,2-a]quinoxaline

Lösungsmittel

ethyl alcohol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture is filtered through a pad of diatomaceous earth
2. 2
   EinengenThe filtrate is concentrated in vacuo to a solid which
3. 3
   Sonstigeis purified by flash chromatography

Vorschrift

A mixture of 1 mmol of 4,5-dihydro-5-(4-nitrobenzoyl)pyrrolo[1,2-a]quinoxaline in 10 ml of ethyl alcohol and 10 ml of ethyl acetate containing 0.2 g of 10% Pd/C is hydrogenated for 5 hours. The reaction mixture is filtered through a pad of diatomaceous earth. The filtrate is concentrated in vacuo to a solid which is purified by flash chromatography to give the desired product, m.p. 225°-228° C.

Quelle