Reaktion #361871

Reaktionsgleichung

N-Chloromethyl-4-nitrophthalimide

4-mercaptopyridine

triethylamine

→

desired compound

Ausbeute 63.1%

4-[(4-nitrophthalimido)methylthio]pyridine

Ausbeute 63.1%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling
2. 2
   workup.DISTILLATIONThe solvent was distilled off
3. 3
   Sonstigethe residue was purified by column chromatography (eluent: ethyl acetate)

Vorschrift

N-Chloromethyl-4-nitrophthalimide [2.89 g (12 mmol)] was added under ice-cooling with stirring to a suspension of 1.11 g (10 mmol) of 4-mercaptopyridine and 1.4 ml (12 mmol) of triethylamine in 50 ml of ethanol. The mixture was stirred at room temperature for 16 hours. The solvent was distilled off and the residue was purified by column chromatography (eluent: ethyl acetate) to obtain 1.99 g of the desired compound (yield: 63.1% yellow crystals).

Quelle