Reaktion #361774

Reaktionsgleichung

o-bromobenzoic acid

N, N'-dicyclohexyl carbodiimide

t-butanol

→

oil

1,1-Dimethylethyl 2-bromobenzoate

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe resulting precipitate was filtered off
2. 2
   Sonstigethe filtrate evaporated
3. 3
   Sonstigeto give a colourless solid which
4. 4
   Sonstigewas triturated under petroleum ether (40°-600°) (20 ml)
5. 5
   Filtrationfiltered
6. 6
   SonstigeThe filtrate was evaporated

Vorschrift

A solution of o-bromobenzoic acid (1 g), N, N'-dicyclohexyl carbodiimide (1.129 g), t-butanol (405 mg) and 4-dimethylaminopyridine (61 mg) in dry ether (20 ml) was stirred at room temperature for 18 h. The resulting precipitate was filtered off and the filtrate evaporated to give a colourless solid which was triturated under petroleum ether (40°-600°) (20 ml) and filtered. The filtrate was evaporated to give a pale yellow oil (0,994 g). b.p. 80°-84°/0.35 mmHg.

Quelle