Reaktion #361372

ord-db5d81ba296448508164311af7e44f6e

Reaktionsgleichung

CC(C)(C)CC(C)(CO)C(=O)O
2-methyl-2-neopentyl-3-hydroxypropionic acid
CCC([O-])([O-])OC
methyl orthopropionate
→
CC(C)(C)CC1(C)COC1=O
desired final product
CC(C)(C)CC1(C)COC1=O
α-methyl-α-neopentyl-β-propiolactone

Edukte

CC(C)(C)CC(C)(CO)C(=O)O
2-methyl-2-neopentyl-3-hydroxypropionic acid
CCC([O-])([O-])OC
methyl orthopropionate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturby slow heating in the presence of Amberlyst® 15

Vorschrift

The resultant 2-methyl-2-neopentyl-3-hydroxypropionic acid (2.) was then reacted conventionally with methyl orthopropionate, followed by slow heating in the presence of Amberlyst® 15, then worked up to obtained the desired final product.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05389447uspto-grants-1995_02