Reaktion #361371

Reaktionsgleichung

acid ( 1 )

2-methyl-2-neopentyl-3-acetoxypropionic acid

sodium hydroxide

HCl

→

2-methyl-2-neopentyl-3-hydroxypropionic acid

Ausbeute 85.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled
2. 2
   SonstigeAfter drying

Vorschrift

In a 100 mL 3-necked RB flask, acid (1) (4.8 g, 0.022 mol) was stirred at reflux with a solution of sodium hydroxide (4.0 g) in water (40 mL) for 20 hours. The mixture was cooled and acidified with concentrated HCl. After drying, there was obtained 2-methyl-2-neopentyl-3-hydroxypropionic acid (2) (3.2 g, 85% yield), m.p. 96.5°-100° C.; recrystallized from n-hexane, m.p. 99°-101° C. 1H NMR (CDCl3): 0.97 (s, 9H), 1.31 (s, 3H), 1.74, 1.54 (AB, 2H), 3.88, 3.40 (AB, 2H), ca. 6.75 (s broad, 2H).

Quelle