Reaktion #361358

Reaktionsgleichung

sodium borohydride

ethanol

chloroform

2-(4-acetylphenyl)-5-decyloxypyrimidine

→

2-{4-(1-hydroxyethyl)phenyl}-5-decyloxypyrimidine

Ausbeute 99.9%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhile maintaining the temperature at 30° to 35° C.
2. 2
   Extraktionextracted with 400 ml of ethyl acetate
3. 3
   WaschenThe organic phase was washed sufficiently
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

Vorschrift

To a mixed solvent of 200 ml of ethanol and 100 ml of chloroform were added 35.5 g (0.1 mole) of 2-(4-acetylphenyl)-5-decyloxypyrimidine, and while maintaining the temperature at 30° to 35° C., 2.65 g (0.07 mole) of sodium borohydride were gradually added thereto. After stirring at the same temperature for 4 hours, the reaction mixture was poured into 500 ml of water and extracted with 400 ml of ethyl acetate. The organic phase was washed sufficiently, dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure to obtain 35.6 g (yield: 99.9%) of 2-{4-(1-hydroxyethyl)phenyl}-5-decyloxypyrimidine.

Quelle