Reaktion #361189

Reaktionsgleichung

4-[6-bromo-1-[(4-methylphenyl)thio]heptyl]-1,2-dimethoxybenzene

5,6-dimethoxyisoindoline

6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline

→

desired product

Ausbeute 65.7%

2-[7-(3,4-Dimethoxyphenyl)-7-[(4-methylphenyl)thio]-heptyl]-1,2,3,4-tetrahydro-6,7,8-trimethoxyisoquinoline

Ausbeute 65.7%

Reaktionsbedingungen

Vorschrift

The procedure of Example 49 is repeated using 5.31 g 4-[6-bromo-1-[(4-methylphenyl)thio]heptyl]-1,2-dimethoxybenzene, 3.29 g of 5,6-dimethoxyisoindoline and 2.65 g of 6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline. This affords 4.52 g of the desired product as a yellow oil.

Quelle