Reaktion #361158

Reaktionsgleichung

α-chloro-3,4-dimethoxybenzeneacetonitrile

p-thiocresol

potassium carbonate

acetonitrile

→

desired compound

Ausbeute 65.4%

3,4-Dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile

Ausbeute 65.4%

Lösungsmittel

hexane

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter filtering off the salts
2. 2
   Einengenthe reaction mixture is concentrated in vacuo
3. 3
   Sonstigeleaving a golden oil

Vorschrift

A mixture of 4.12 g of α-chloro-3,4-dimethoxybenzeneacetonitrile (U.S. Pat. No. 4,833,162), 2.48 g of p-thiocresol, 2.76 g of potassium carbonate and 100 mL of acetonitrile is stirred at 65° C. overnight. After filtering off the salts, the reaction mixture is concentrated in vacuo leaving a golden oil. The oil is dissolved in a minimum amount of ethyl acetate and diluted with 3 volumes of hexane. Seeding gives 3.81 g of the desired compound as light yellow crystals.

Quelle