Reaktion #360437

ord-03713faf71dc4e8fa2470049d9690cb2

Reaktionsgleichung

CCCC(CCC)C(=O)[O-].CCCC(CCC)C(=O)[O-].C[N+](C)(C)C[C@H](O)CC(=O)[O-].[Mg+2]
L-carnitine magnesium valproate
CCCC(CCC)C(=O)[O-].CCCC(CCC)C(=O)[O-].C[N+](C)(C)C[C@H](O)CC(=O)[O-].[Mg+2]
L-carnitine magnesium valproate
C[N+](C)(C)C[C@H](O)CC(=O)[O-]
L-carnitine
C[N+](C)(C)C[C@H](O)CC(=O)[O-]
L-carnitine
CCCC(CCC)C(=O)O
valproic acid
CCCC(CCC)C(=O)[O-].CCCC(CCC)C(=O)[O-].C[N+](C)(C)C[C@H](O)CC(=O)[O-].[Mg+2]
L-Carnitine magnesium valproate
CCCC(CCC)C(=O)[O-].CCCC(CCC)C(=O)[O-].C[N+](C)(C)C[C@H](O)CC(=O)[O-].[Mg+2]
L-carnitine magnesium valproate
→
C[N+](C)(C)C[C@H](O)CC(=O)[O-]
L-carnitine
[Mg]
magnesium
CCCC(CCC)C(=O)[O-]
valproate

Edukte

CCCC(CCC)C(=O)[O-].CCCC(CCC)C(=O)[O-].C[N+](C)(C)C[C@H](O)CC(=O)[O-].[Mg+2]
L-carnitine magnesium valproate
CCCC(CCC)C(=O)[O-].CCCC(CCC)C(=O)[O-].C[N+](C)(C)C[C@H](O)CC(=O)[O-].[Mg+2]
L-carnitine magnesium valproate
C[N+](C)(C)C[C@H](O)CC(=O)[O-]
L-carnitine
C[N+](C)(C)C[C@H](O)CC(=O)[O-]
L-carnitine
CCCC(CCC)C(=O)O
valproic acid
CCCC(CCC)C(=O)[O-].CCCC(CCC)C(=O)[O-].C[N+](C)(C)C[C@H](O)CC(=O)[O-].[Mg+2]
L-Carnitine magnesium valproate
CCCC(CCC)C(=O)[O-].CCCC(CCC)C(=O)[O-].C[N+](C)(C)C[C@H](O)CC(=O)[O-].[Mg+2]
L-carnitine magnesium valproate

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

As we discovered and disclose in Example 2, L-carnitine magnesium valproate, another embodiment of the present invention, is a white solid having a melting point of 77.2° C., different from the melting point of L-carnitine. The 1H-NMR spectrum of L-carnitine magnesium valproate (FIG. 3) differs from that of the starting materials (i.e., L-carnitine and valproic acid) and confirms the structure. L-carnitine magnesium valproate is nearly odorless and free from objectionable taste. L-Carnitine magnesium valproate is soluble in water, and aqueous solutions of this salt provide bioavailable L-carnitine, magnesium, and valproate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07456216B2uspto-grants-2008_11