Reaktion #360000

Reaktionsgleichung

DCM MeOH NH3

4-(4-Dimethylaminomethyl-tetrahydro-pyran-4-yl)-phenol

4-(3-chloro-propyl)-thiomorpholine

K2CO3

→

title compound

Ausbeute 39.7%

Dimethyl-{4-[4-(3-thiomorpholin-4-ylpropoxy)phenyl]tetra-hydro-pyran-4-ylmethyl}amine

Ausbeute 39.7%

Lösungsmittel

DMF

Reaktionsbedingungen

Vorschrift

4-(4-Dimethylaminomethyl-tetrahydro-pyran-4-yl)-phenol (1000 mg, 4.25 mmol), 4-(3-chloro-propyl)-thiomorpholine (764 mg, 2,13 mmol), DMF (20 ml), and K2CO3 (2.34 g, 17 mmol) were reacted together according to general procedure B. The isolated material was subjected to chromatography on silica, eluant DCM:MeOH:NH3 (95:5:1) to give the title compound (320 mg, 20%). 1H NMR (400 MHz, CDCl3) δ 7.20 (d, 2H), 6.86 (d, 2H), 3.99 (t, 2H), 3.75 (dt, 2H), 3.55 (td, 2H), 2.79-2.64 (m, 8H), 2.55 (t, 2H), 2.40 (s, 2H), 2.16-2.04 (m, 2H), 2.01-1.82 (m, 4H), 1.97 (s, 6H).

Quelle