Reaktion #359814

Reaktionsgleichung

2,4-Dichloro-5-iodo-pyrimidine

triethylamine

(R)-2-Amino-3-methyl-butan-1-ol

→

(R)-2-(2-Chloro-5-iodo-pyrimidin-4-ylamino)-3-methyl-butan-1-ol

Lösungsmittel

acetonitrile

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe batch is filtered
2. 2
   Waschenthe solid is washed with small amounts of acetonitrile and water
3. 3
   SonstigeThe solid is dried
4. 4
   Sonstige10.24 g (30.0 mmol, corresponding to 82% of theory) of the product is obtained

Vorschrift

A solution of 10.05 g (36.6 mmol) of 2,4-Dichloro-5-iodo-pyrimidine and 5.6 ml (40.0 mmol) triethylamine in 30 ml of acetonitrile is mixed with 4.85 g (47.0 mmol) of (R)-2-Amino-3-methyl-butan-1-ol. The batch is stirred at room temperature for 16 hours and is finally diluted with water. The batch is filtered and the solid is washed with small amounts of acetonitrile and water. The solid is dried. 10.24 g (30.0 mmol, corresponding to 82% of theory) of the product is obtained.

Quelle