Reaktion #3598

Reaktionsgleichung

2-methyl-N-[4-(pyrrolo[1,2-a]quinoxalin-5(4H)-ylcarbonyl)-phenyl]benzamide

N-chlorosuccinimide

→

desired product

2-Methyl-N-[4-(1-chloropyrrolo[1,2-a]quinoxalin-5(4H)-ylcarbonyl)phenyl]benzamide

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe bath is removed
2. 2
   workup.STIRRINGstirring
3. 3
   workup.WAITcontinued for 2.25 hours
4. 4
   workup.ADDITIONThe reaction mixture is added to ice-water
5. 5
   Extraktionextracted with ether
6. 6
   SonstigeThe organic layer is dried
7. 7
   Einengenconcentrated in vacuo

Vorschrift

To an ice-water cooled suspension of 5 mmol of 2-methyl-N-[4-(pyrrolo[1,2-a]quinoxalin-5(4H)-ylcarbonyl)-phenyl]benzamide in 5 ml of tetrahydrofuran is added 5.5 mmol of N-chlorosuccinimide followed by continued stirring in the cold for 10 minutes. The bath is removed and stirring continued for 2.25 hours. The reaction mixture is added to ice-water and extracted with ether. The organic layer is dried and concentrated in vacuo to give the desired product as a solid.

Quelle