Reaktion #3596

Reaktionsgleichung

10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

triethylamine

4-[(2-methylbenzoyl)amino]benzoyl chloride

→

desired product

2-Methyl-N-[4-[(5-oxo-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl)carbonyl]phenyl]benzamide

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe volatiles are removed in vacuo to a residue which
2. 2
   Sonstigeis purified on thick layer chromatography plates with 7:3 hexane-ethyl acetate

Vorschrift

To a stirred solution of 107 mg of 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one in 3 ml of methylene chloride containing 0.084 ml of triethylamine is added 165 mg of 4-[(2-methylbenzoyl)amino]benzoyl chloride and stirring continued for 6 hours. The volatiles are removed in vacuo to a residue which is purified on thick layer chromatography plates with 7:3 hexane-ethyl acetate to afford the desired product as a foam.

Quelle