Reaktion #357762

Reaktionsgleichung

tert-Butyl [(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl}carbonyl)cyclopentyl]carbamate

→

desired product

Ausbeute 116.8%

(1R,3S)-3-Isopropyl-3-({4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl}carbonyl)cyclopentanamine

Ausbeute 116.8%

Lösungsmittel

—

solution

HCl

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe mixture was concentrated

Vorschrift

tert-Butyl [(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl}carbonyl)cyclopentyl]carbamate (290 mg, 0.60 mmol) was dissolved in a 4.0 M solution of HCl in 1,4-dioxane (10 mL). After being stirred at room temperature for 1 h, the mixture was concentrated to give 270 mg of desired product. MS calculated for C18H26F3N5O: (M+H) 386; found 386.1.

Quelle