Reaktion #357727

ord-f7d547762e5b4efbbe9d14fb453e5a51

Reaktionsgleichung

COCC1COCCC1=O
3-(methoxymethyl)tetrahydro-4H-pyran-4-one
CC(C)[C@]1(C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC[C@@H](N)C1
(1R,3S)-3-isopropyl-3-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)cyclopentanamine
→
COCC1COCCC1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)(C(C)C)C1
title compound
COCC1COCCC1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)(C(C)C)C1
N-[(1R,3S)-3-isopropyl-3-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)cyclopentyl]-3-(methoxymethyl)tetrahydro-2H-pyran-4-amine

Edukte

COCC1COCCC1=O
3-(methoxymethyl)tetrahydro-4H-pyran-4-one
CC(C)[C@]1(C(=O)N2CCN(c3cccc(C(F)(F)F)c3)CC2)CC[C@@H](N)C1
(1R,3S)-3-isopropyl-3-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)cyclopentanamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared by reductive amination of 3-(methoxymethyl)tetrahydro-4H-pyran-4-one with (1R,3S)-3-isopropyl-3-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)cyclopentanamine using the procedure described for Example 5. MS calculated for C27H40F3N3O3: (M+H) 512; found 512.2.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07449467B2uspto-grants-2008_11