Reaktion #357600

ord-59ea327eb33b499381a6ccfc1bf58f03

Reaktionsgleichung

Fc1ccc(-c2csc3cc(OCCCCBr)ccc23)cc1
6-(4-Bromo-butoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene
C1CNC1
azetidine
Fc1ccc(-c2csc3cc(OCCCCN4CCC4)ccc23)cc1
1-{4-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-butyl}-azetidine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to example 3.1, 6-(4-Bromo-butoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene and azetidine were converted to yield 1-{4-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-butyl}-azetidine as colorless oil, MS: 356 (MH+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07449483B2uspto-grants-2008_11