Reaktion #357597

ord-f26a8ae9b891441da741f4dcd79c03c8

Reaktionsgleichung

Fc1ccc(-c2csc3cc(OCCCCBr)ccc23)cc1
6-(4-Bromo-butoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene
OCCNCCO
diethanolamine
OCCN(CCO)CCCCOc1ccc2c(-c3ccc(F)cc3)csc2c1
2-[{4-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-butyl}-(2-hydroxy-ethyl)-amino]-ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to example 3.1, 6-(4-Bromo-butoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene and diethanolamine were converted to yield 2-[{4-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-butyl}-(2-hydroxy-ethyl)-amino]-ethanol as white semisolid, MS: 404 (MH+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07449483B2uspto-grants-2008_11