Reaktion #357594

ord-1678375aa6804da8b48393d02ba0ca8b

Reaktionsgleichung

Fc1ccc(-c2csc3cc(OCCCCBr)ccc23)cc1
6-(4-Bromo-butoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene
CNCCOC
N-(2-methoxyethyl)methylamine
COCCN(C)CCCCOc1ccc2c(-c3ccc(F)cc3)csc2c1
{4-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-butyl}-(2-methoxy-ethyl)-methyl-amine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to example 3.1, 6-(4-Bromo-butoxy)-3-(4-fluoro-phenyl)-benzo[b]thiophene and N-(2-methoxyethyl)methylamine were converted to yield {4-[3-(4-Fluoro-phenyl)-benzo[b]thiophen-6-yloxy]-butyl}-(2-methoxy-ethyl)-methyl-amine as colorless oil, MS: 388 (MH+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07449483B2uspto-grants-2008_11