Reaktion #3575

Reaktionsgleichung

2,7-diamino-6-(3-pyridyl)-pyrido[2,3-d]pyrimidine

6-Pyridin-3-yl-pyrido[2,3-d]pyrimidine-2,7-diamine

tert-butyl isocyanate

→

title compound

1-(2-Amino-6-pyridin-3-yl-pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl-urea

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was purified by medium pressure chromatography
2. 2
   Wascheneluting with 90:10

Vorschrift

By following the procedure of Example 2, 0.30 g of 2,7-diamino-6-(3-pyridyl)-pyrido[2,3-d]pyrimidine from Example 107 was reacted with 0.16 mL of tert-butyl isocyanate. The product was purified by medium pressure chromatography using silica gel and eluting with 90:10:1EtOAc:MeOH:TEA to afford the title compound; mp >300° C.; CIMS (1% ammonia in methane): m/z (relative intensity) 338 (MH+ +1, 8), 339 (MH+ +2, 1), 84 (100).

Quelle