Reaktion #357328

Reaktionsgleichung

2-ethylphenol

potassium carbonate

ethylbromoacetate

→

product

Ausbeute 82.0%

Ethyl (2-ethylphenoxy)acetate

Ausbeute 82.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling to room temperature the reaction mixture
2. 2
   Sonstigewas partitioned between ethyl ether and 1N NaOH
3. 3
   SonstigeThe phases were separated
4. 4
   Waschenthe organic portion washed twice with 1N NaOH, twice with H2O, brine
5. 5
   Trocknendried over Na2SO4
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated in vacuo

Vorschrift

To a stirred solution of 2-ethylphenol (5ml, 42.4mmoles, 1eq) in dry DMF (120ml, 0.35M) was added potassium carbonate (6.45g, 46.6mmoles, 1.1eq) and ethylbromoacetate (4.7ml, 42.2mmoles, 1eq) and heated to 60° C. overnight. After cooling to room temperature the reaction mixture was partitioned between ethyl ether and 1N NaOH. The phases were separated and the organic portion washed twice with 1N NaOH, twice with H2O, brine, dried over Na2SO4, filtered and concentrated in vacuo to yield 7.2g (82%) of product.

Quelle