Reaktion #357202

ord-cd92d958d05e42f3a0b0bebcdb3da072

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCN(c2ccc(CCCN3CCOCC3)cc2)CC1
solution
CC(C)(C)OC(=O)N1CCN(c2ccc(CCCN3CCOCC3)cc2)CC1
tert-butyl 4-[4-(3-morpholin-4-ylpropyl)phenyl]piperazine-1-carboxylate
O=C(O)C(F)(F)F
TFA
O
water
→
O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.c1cc(N2CCNCC2)ccc1CCCN1CCOCC1
desired product
O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.c1cc(N2CCNCC2)ccc1CCCN1CCOCC1
4-[3-(4-piperazin-1-ylphenyl)propyl]morpholine tris(trifluoroacetate)

Edukte

CC(C)(C)OC(=O)N1CCN(c2ccc(CCCN3CCOCC3)cc2)CC1
solution
CC(C)(C)OC(=O)N1CCN(c2ccc(CCCN3CCOCC3)cc2)CC1
tert-butyl 4-[4-(3-morpholin-4-ylpropyl)phenyl]piperazine-1-carboxylate
O=C(O)C(F)(F)F
TFA
O
water

Reagenzien

Keine

Lösungsmittel

ClCCl
dichloromethane

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    EinengenThe solution was concentrated

Vorschrift

A solution of Example 5B (671 mg, 1.725 mmol) in dichloromethane (2 mL) at room temperature was treated with TFA (1.8 mL) and water (0.2 mL) allowed to stand for 2 hours The solution was concentrated to provide the desired product.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07449485B2uspto-grants-2008_11