Reaktion #357099

Reaktionsgleichung

1-(2,5-difluoro-4-methoxyphenyl)-4-piperidinecarbaldehyde

methoxymethyltriphenylphosphonium chloride

1-(2,5-difluoro-4-methoxyphenyl)piperidin-4-one

phenethyltri-phenylphosphonium bromide

→

(Z)-1-(2,5-difluoro-4-methoxyphenyl)-4-(3-phenyl-1-propen-1-yl)piperidine

Ausbeute 78.6%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigerespectively, and the resulting crude product was purified on TLC (developer, hexane: ethyl acetate=10:1)

Vorschrift

Production Example 74 was repeated except that methoxymethyltriphenylphosphonium chloride and 1-(2,5-difluoro-4-methoxyphenyl)piperidin-4-one were replaced with phenethyltri-phenylphosphonium bromide (133 mg) and 1-(2,5-difluoro-4-methoxyphenyl)-4-piperidinecarbaldehyde (35 mg), respectively, and the resulting crude product was purified on TLC (developer, hexane: ethyl acetate=10:1) to provide (Z)-1-(2,5-difluoro-4-methoxyphenyl)-4-(3-phenyl-1-propen-1-yl)piperidine (37 mg).

Quelle