Reaktion #356985

Reaktionsgleichung

diisopropylethylamine

4-Fluoronitrobenzene

2,6-dimethylmorpholine

→

cis-4-(2,6-dimethylmorpholin-4-yl)aniline

trans-4-(2,6-dimethylmorpholin-4-yl)aniline

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigecis and trans isomers were separated
2. 2
   Sonstigepurified by a silica gel column chromatography

Vorschrift

4-Fluoronitrobenzene and 2,6-dimethylmorpholine were allowed to undergo the reaction in DMF in the presence of diisopropylethylamine, and then cis and trans isomers were separated and purified by a silica gel column chromatography and respectively subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain cis-4-(2,6-dimethylmorpholin-4-yl)aniline (Reference Example 7; F: 207) and trans-4-(2,6-dimethylmorpholin-4-yl)aniline (Reference Example 8; F: 207).

Quelle