Reaktion #356769

Reaktionsgleichung

ethyl 5-bromonicotinate

{2′-[(phenylmethyl)oxy]-2-biphenylyl}boronic acid

potassium carbonate

→

colourless gum

Ausbeute 80.6%

Ethyl 5-{2′-[(phenylmethyl)oxy]-2-biphenylyl}-3-pyridinecarboxylate

Ausbeute 80.6%

Lösungsmittel

ether water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling the mixture
2. 2
   Trocknenthe organic phase dried (magnesium sulphate)
3. 3
   Sonstigeevaporated
4. 4
   Sonstigechromatographed on silica eluting with ethyl acetate/iso-hexane (1:5)

Vorschrift

A mixture of ethyl 5-bromonicotinate (46 mg, 0.2 mmol), {2′-[(phenylmethyl)oxy]-2-biphenylyl}boronic acid (61 mg, 0.2 mmol), potassium carbonate (221 mg, 1.6 mmol) and tetrakis(triphenylphosphine)palladium(0) (23 mg, 0.02 mmol) was stirred and heated at 90° C. under nitrogen for 2 hours. After cooling the mixture was diluted with ether/water and the organic phase dried (magnesium sulphate), evaporated and chromatographed on silica eluting with ethyl acetate/iso-hexane (1:5) to give 66 mg of colourless gum.

Quelle