Reaktion #356598

Reaktionsgleichung

methyl 4-fluoro-5-methanesulfonyl-2-methylbenzoate

3-pentafluorosulfanylphenol

Cs2CO3

→

colorless oil

Ausbeute 27.6%

Methyl 5-methanesulfonyl-2-methyl-4-(3-pentafluorosulfanylphenoxy)benzoate

Ausbeute 27.6%

Lösungsmittel

DMF

EA

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed 3 times with 20 ml of water each time
2. 2
   TrocknenThe residue after drying over MgSO4 and removal of the solvent in vacuo
3. 3
   Sonstigewas chromatographed on silica gel with DIP

Vorschrift

600 mg of methyl 4-fluoro-5-methanesulfonyl-2-methylbenzoate, 700 mg of 3-pentafluorosulfanylphenol and 1.6 g of Cs2CO3 were stirred in 4 ml of anhydrous DMF at 100° C. for 3 h. The mixture was then cooled to RT, diluted with 100 ml of EA and washed 3 times with 20 ml of water each time. The residue after drying over MgSO4 and removal of the solvent in vacuo was chromatographed on silica gel with DIP. 300 mg of a colorless oil were obtained.

Quelle