Reaktion #356329

ord-e9b209128c6d44c7afa6f560641b9d6f

Reaktionsgleichung

C#Cc1cnn2c(C3CC3)cc(-c3ccc(Cl)cc3)nc12
5-(4-chloro-phenyl)-7-cyclopropyl-3-ethynyl-pyrazolo[1,5-a]pyrimidine
NS(=O)(=O)c1ccc(Br)s1
5-bromo-thiophene-2-sulfonic acid amide
→
NS(=O)(=O)c1ccc(C#Cc2cnn3c(C4CC4)cc(-c4ccc(Cl)cc4)nc23)s1
title compound
NS(=O)(=O)c1ccc(C#Cc2cnn3c(C4CC4)cc(-c4ccc(Cl)cc4)nc23)s1
5-[5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-thiophene-2-sulfonic acid amide

Edukte

C#Cc1cnn2c(C3CC3)cc(-c3ccc(Cl)cc3)nc12
5-(4-chloro-phenyl)-7-cyclopropyl-3-ethynyl-pyrazolo[1,5-a]pyrimidine
NS(=O)(=O)c1ccc(Br)s1
5-bromo-thiophene-2-sulfonic acid amide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from 5-(4-chloro-phenyl)-7-cyclopropyl-3-ethynyl-pyrazolo[1,5-a]pyrimidine (example C.5) (73 mg, 0.25 mmol) and 5-bromo-thiophene-2-sulfonic acid amide (61 mg, 0.25 mmol) according to general procedure II. Obtained as a yellow solid (52 mg, 45%). MS (ISP) 445.4 [(M+H)+]; mp 218-220° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07446113B2uspto-grants-2008_11