Reaktion #356266

Reaktionsgleichung

5-bromo-thiophene-2-sulfonic acid amide

trimethylsilylacetylene

→

5-Ethynyl-thiophene-2-sulfonic acid amide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeObtained
2. 2
   Sonstigeafter chromatographic purification of the crude product (SiO2, 0-75% AcOEt/heptane) as a light brown solid (0.49 g, 33%)

Vorschrift

Prepared from 5-bromo-thiophene-2-sulfonic acid amide (1.94 g, 8 mmol) and trimethylsilylacetylene (2.2 mL, 12 mmol) by applying in analogous manner the procedures described in example D.1 (method 1, steps 1-2). Obtained after chromatographic purification of the crude product (SiO2, 0-75% AcOEt/heptane) as a light brown solid (0.49 g, 33%). MS (ISP) 186.1 [(M−H)−]; mp 114-116° C.

Quelle