Reaktion #3559

ord-402f050ecfe844a4a9c4948e241fc170

Reaktionsgleichung

Cc1ccccc1-c1cc2cnc(N)nc2nc1N
6-o-tolyl-pyrido[2,3-d]pyrimidine-2,7-diamine
Cc1ccccc1-c1cc2cnc(N)nc2nc1N
6-o-Tolyl-pyrido[2,3-d]pyrimidine-2,7-diamine
CC(C)(C)N=C=O
tert-butyl isocyanate
N
ammonia
→
Cc1ccccc1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
title compound
Cc1ccccc1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
1-(2-Amino-6-o-tolyl-pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl-urea

Edukte

—
( 100 )
Cc1ccccc1-c1cc2cnc(N)nc2nc1N
6-o-tolyl-pyrido[2,3-d]pyrimidine-2,7-diamine
Cc1ccccc1-c1cc2cnc(N)nc2nc1N
6-o-Tolyl-pyrido[2,3-d]pyrimidine-2,7-diamine
CC(C)(C)N=C=O
tert-butyl isocyanate
N
ammonia

Reagenzien

Keine

Lösungsmittel

C
methane

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe product was purified by MPLC
  2. 2
    Wascheneluting with CHCl3 :EtOAc (1:1)
  3. 3
    Sonstigeafford the pure product

Vorschrift

The title compound was prepared from 6-o-tolyl-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 90 and tert-butyl isocyanate according to Example 2. The product was purified by MPLC eluting with CHCl3 :EtOAc (1:1) afford the pure product; mp 195°-197° C., CIMS (1% ammonia in methane): m/z (relative intensity) 351 (MH+ +1, 55), 352 (MH+ +2, 12), 84 (100).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05733913uspto-grants-1998_03