Reaktion #355750

Reaktionsgleichung

5-fluoro-2-nitrotoluene

N-methylpyrrolidinone

4-amino-2-butanol

triethylamine

→

4-(4-nitro-3-methylphenylamino)butan-2-ol

Ausbeute 99.6%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturafter cooling to room temperature
2. 2
   ExtraktionThe resulting medium was extracted with ethyl acetate
3. 3
   Einengenthe organic phase was then concentrated under vacuum

Vorschrift

2 g of 5-fluoro-2-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.38 g of 4-amino-2-butanol and 1.57 g of triethylamine. The reaction medium was heated at 60° C. for 10 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The resulting medium was extracted with ethyl acetate and the organic phase was then concentrated under vacuum. 2.88 g of 4-(4-nitro-3-methylphenylamino)butan-2-ol (31) were obtained.

Quelle