Reaktion #355742

Reaktionsgleichung

5-fluoro-2-nitrotoluene

N-methylpyrrolidinone

2-aminoethoxyethanol

K2CO3

→

2-[2-(4-nitro-3-methylphenylamino)ethoxy]ethanol

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturafter cooling to room temperature
2. 2
   SonstigeThe yellow precipitate formed
3. 3
   Filtrationwas filtered off
4. 4
   Trocknendried over P2O5

Vorschrift

2 g of 5-fluoro-2-nitrotoluene were added to a solution of 20 ml of N-methylpyrrolidinone, 1.63 g of 2-aminoethoxyethanol and 2.14 g of K2CO3. The reaction medium was heated at 60° C. for 12 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 1.9 g of 2-[2-(4-nitro-3-methylphenylamino)ethoxy]ethanol (15) were obtained after purification on a column of silica.

Quelle