Reaktion #3557

Reaktionsgleichung

6-(2,6-dichlorophenyl)-pyrido{2,3-d]pyrimidine-2,7-diamine

2,7-diamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidine

isopropyl isocyanate

ammonia

→

title compound

1-[2-Amino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-isopropyl-urea

Lösungsmittel

methane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was purified by MPLC
2. 2
   Wascheneluting with a gradient of CHCl3 :EtOAc (1:1)
3. 3
   Sonstigeto afford the pure product

Vorschrift

The title compound was prepared from 0.5 g of 6-(2,6-dichlorophenyl)-pyrido{2,3-d]pyrimidine-2,7-diamine from Example 1 and 0.172 mL of isopropyl isocyanate according to Example 2. The product was purified by MPLC eluting with a gradient of CHCl3 :EtOAc (1:1) to afford the pure product; mp 184°-188° C., CIMS (1% ammonia in methane): m/z (relative intensity) 391 (MH+, 16), 393 (MH+ +2, 11), 306 (100).

Quelle