Reaktion #3552

Reaktionsgleichung

6-(2,3-dichlorophenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

6-(2,3-Dichlorophenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine

tert-butyl isocyanate

→

title compound

1-[2-Amino-6-(2,3-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl-urea

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product is purified by silica gel chromatography
2. 2
   Wascheneluting with a gradient of CHCl3 :EtOAc (98:2) to CHCl3 :EtOAc (1:2)

Vorschrift

Following the general procedure of Example 2, 0.502 g of 6-(2,3-dichlorophenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 83 was reacted with 0.206 mL of tert-butyl isocyanate. The product is purified by silica gel chromatography eluting with a gradient of CHCl3 :EtOAc (98:2) to CHCl3 :EtOAc (1:2) to afford the title compound; mp 356°-358° C.

Quelle