Reaktion #355011

Reaktionsgleichung

3-dimethylamino-4'-fluoro-2-methylpropiophenone

sulfuric acid

→

5-fluoro-2-methyl-1-indanone

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 42 g
2. 2
   TemperaturThe reaction is cooled
3. 3
   Sonstigequenched in ice
4. 4
   Extraktionthe product extracted into toluene
5. 5
   WaschenThe toluene layer is washed with aqueous sodium hydroxide and water
6. 6
   Einengenconcentrated in vacuo

Vorschrift

A mixture of 42 g. (0.20 mole) of 3-dimethylamino-4'-fluoro-2-methylpropiophenone and 100 ml. of concentrated sulfuric acid is warmed to 90°C over one hour and stirred at 90°C for two hours. The reaction is cooled and quenched in ice and the product extracted into toluene. The toluene layer is washed with aqueous sodium hydroxide and water and concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

Quelle