Reaktion #355010

Reaktionsgleichung

4'-fluoropropiophenone

dimethylamine hydrochloride

paraformaldehyde

→

3-dimethylamino-4'-fluoro-2methylpropiophenone

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 15.2 g
2. 2
   TemperaturThe mixture is cooled
3. 3
   Filtrationthe precipitated product is filtered
4. 4
   workup.DISSOLUTIONThe product is dissolved in water
5. 5
   ExtraktionThe free base is extracted into ether
6. 6
   TrocknenThe ether layer is dried over anhydrous sodium sulfate
7. 7
   Einengenconcentrated in vacuo

Vorschrift

A mixture of 15.2 g. (0.10 mole) of 4'-fluoropropiophenone, 8.2 g. (0.10 mole) of dimethylamine hydrochloride, 3.6 g. (0.12 mole) of paraformaldehyde in 20 ml. of absolute alcohol was stirred at 95°-100°C for three hours. The mixture is cooled and the precipitated product is filtered. The product is dissolved in water, made alkaline with sodium hydroxide. The free base is extracted into ether. The ether layer is dried over anhydrous sodium sulfate and concentrated in vacuo to give 3-dimethylamino-4'-fluoro-2methylpropiophenone

Quelle