Reaktion #355008

Reaktionsgleichung

aluminum chloride

fluorobenzene

β-chloroisobutyrylchloride

→

3-chloro-4'-fluoro-2-methylpropiophenone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigequenched in ice
2. 2
   ExtraktionThe product is extracted into hexane
3. 3
   TrocknenThe hexane layer is dried over anhydrous sodium sulfate
4. 4
   Einengenconcentrated in vacuo

Vorschrift

To a slurry of 22.7 g. (0.17 mole) of anhydrous aluminum chloride and 9.6 g. (0.10 mole) of fluorobenzene is added 14.1 g. (0.10 mole) of β-chloroisobutyrylchloride over 30 minutes at 20°-25°C. The mixture is aged for 30 minutes at 20°-25°C and then quenched in ice. The product is extracted into hexane. The hexane layer is dried over anhydrous sodium sulfate and concentrated in vacuo to give 3-chloro-4'-fluoro-2-methylpropiophenone.

Quelle