Reaktion #3550

Reaktionsgleichung

6-phenyl-pyrido[2,3-d]pyrimidine-2,7-diamine

6-Phenyl-pyrido[2,3-d]pyrimidine-2,7-diamine

tert-butyl isocyanate

→

title compound

1-(2-Amino-6-phenyl-pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl-urea

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product is purified by medium pressure chromatography
2. 2
   Wascheneluting with a gradient of 1:1 CHCl3

Vorschrift

Following the procedure of Example 2, 0.246 g of 6-phenyl-pyrido[2,3-d]pyrimidine-2,7-diamine from Example 81 was reacted with 0.128 mL of tert-butyl isocyanate. The product is purified by medium pressure chromatography using silica gel and eluting with a gradient of 1:1 CHCl3 :EtOAc to EtOAc to afford the title compound; mp >250° C., CIMS (1% ammonia in methane): m/z (relative intensity) 337 (MH+ +1, 64), 338 (MH+ +2, 11), 236 (100).

Quelle