Reaktion #354974

Reaktionsgleichung

2-(2-hydroxyphenoxy)acetonitrile

2-chloro-2-phenylacetonitrile

potassium carbonate

2-chloro-2-phenylacetonitrile

potassium carbonate

→

2-phenyl-2-(2-cyanomethoxyphenoxy)acetonitrile

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed six hours
2. 2
   FiltrationThe mixture is filtered
3. 3
   Waschenthe solids washed with acetone
4. 4
   Sonstigethe combined filtrate evaporated in vacuo
5. 5
   Sonstigeto give an oil
6. 6
   SonstigeCrystallization of the oil

Vorschrift

A mixture of 2-(2-hydroxyphenoxy)acetonitrile (14.9 g., 0.1 mole), 2-chloro-2-phenylacetonitrile (15.2 g., 0.1 mole), finely powdered potassium carbonate (13.8 g., 0.1 mole) and 80 ml. of acetone is refluxed 3 hours. The mixture is then treated with 2-chloro-2-phenylacetonitrile (7.6 g., 0.05 mole) and potassium carbonate (6.9 g., 0.5 mole) and refluxed six hours. The mixture is filtered, the solids washed with acetone and the combined filtrate evaporated in vacuo to give an oil. Crystallization of the oil affords 2-phenyl-2-(2-cyanomethoxyphenoxy)acetonitrile.

Quelle