Reaktion #354715

ord-3b371539845141dcac9bc4a1d69fe97c

Reaktionsgleichung

[N-]=[N+]=Nc1ccccc1C=O
2-azidobenzaldehyde
CCOC(=O)CC(=O)C(=O)OCC
oxalacetic acid diethyl ester
CCOC(=O)/C=C(/C)N
β-aminocrotonic acid ethyl ester
→
CCOC(=O)C1=C(C(=O)OCC)C(c2ccccc2N=[N+]=[N-])C(C(=O)OCC)=C(C)N1
2-Methyl-4-(2'-azidophenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester

Edukte

[N-]=[N+]=Nc1ccccc1C=O
2-azidobenzaldehyde
CCOC(=O)CC(=O)C(=O)OCC
oxalacetic acid diethyl ester
CCOC(=O)/C=C(/C)N
β-aminocrotonic acid ethyl ester

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeevaporated in vacuo

Vorschrift

A solution of 14.7 g of 2-azidobenzaldehyde, 19 g of oxalacetic acid diethyl ester and 13 g of β-aminocrotonic acid ethyl ester in 40 ccs of ethanol is heated to the boil overnight and evaporated in vacuo. Yellow-brown oil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US03943140uspto-grants-1976_03