Reaktion #354714

ord-dce32b768b0344abbde4b1f5a90ba627

Reaktionsgleichung

O=Cc1cccc(Cl)c1
3-chlorobenzaldehyde
CCOC(=O)CC(=O)C(=O)OCC
oxalacetic acid diethyl ester
CCOC(=O)CC(=N)C(=O)OCC
iminosuccinic acid diethyl ester
→
CCOC(=O)C1=C(C(=O)OCC)C(c2cccc(Cl)c2)C(C(=O)OCC)=C(C(=O)OCC)N1
4-(3'-Chlorophenyl)-1,4-dihydropyridine-2,3,5,6-tetracarboxylic acid tetraethyl ester

Edukte

O=Cc1cccc(Cl)c1
3-chlorobenzaldehyde
CCOC(=O)CC(=O)C(=O)OCC
oxalacetic acid diethyl ester
CCOC(=O)CC(=N)C(=O)OCC
iminosuccinic acid diethyl ester

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigesubsequently evaporated in vacuo

Vorschrift

14.1 g of 3-chlorobenzaldehyde, 19 g of oxalacetic acid diethyl ester and 18.8 g of iminosuccinic acid diethyl ester in 60 ccs of ethanol are heated to the boil overnight and subsequently evaporated in vacuo. Yellow oil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US03943140uspto-grants-1976_03