Reaktion #354712

ord-186bbfb44e8143ec82c2580d78024fcf

Reaktionsgleichung

COc1cccc(C=O)c1
3-methoxybenzaldehyde
CCOC(=O)CC(=O)C(=O)OCC
oxalacetic acid diethyl ester
CCOC(=O)/C=C(/C)N
β-aminocrotonic acid ethyl ester
→
CCOC(=O)C1=C(C(=O)OCC)C(c2cccc(OC)c2)C(C(=O)OCC)=C(C)N1
2-Methyl-4-(3'-methoxyphenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester

Edukte

COc1cccc(C=O)c1
3-methoxybenzaldehyde
CCOC(=O)CC(=O)C(=O)OCC
oxalacetic acid diethyl ester
CCOC(=O)/C=C(/C)N
β-aminocrotonic acid ethyl ester

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeevaporated in vacuo

Vorschrift

27.2 g of 3-methoxybenzaldehyde, 38 g of oxalacetic acid diethyl ester and 26 g of β-aminocrotonic acid ethyl ester in 120 ccs of ethanol are heated to the boil overnight and evaporated in vacuo. Oil (orange).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US03943140uspto-grants-1976_03