Reaktion #354711

ord-82f43cff46cb4195b25e04c06798d61d

Reaktionsgleichung

CCOC(=O)C1=C(C(=O)OCC)C(c2ccccc2Cl)C(C(=O)OCC)=C(C)N1
2-methyl-4-(2'-chlorophenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester
O=Cc1ccccc1Cl
2-chlorobenzaldehyde
CCOC(=O)CC(=O)C(=O)OCC
oxalacetic acid diethyl ester
CCOC(=O)/C=C(/C)N
β-aminocrotonic acid ethyl ester
→
CCOC(=O)C1=C(C(=O)OCC)C(c2cccc(Cl)c2)C(C(=O)OCC)=C(C)N1
2-Methyl-4-(3'-chlorophenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester

Edukte

CCOC(=O)C1=C(C(=O)OCC)C(c2ccccc2Cl)C(C(=O)OCC)=C(C)N1
2-methyl-4-(2'-chlorophenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester
O=Cc1ccccc1Cl
2-chlorobenzaldehyde
CCOC(=O)CC(=O)C(=O)OCC
oxalacetic acid diethyl ester
CCOC(=O)/C=C(/C)N
β-aminocrotonic acid ethyl ester

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In the same way, 2-methyl-4-(2'-chlorophenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester is prepared from 14 g of 2-chlorobenzaldehyde, 19 g of oxalacetic acid diethyl ester and 13 g of β-aminocrotonic acid ethyl ester in 60 ccs of ethanol.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US03943140uspto-grants-1976_03