Reaktion #354710

ord-1be3e2ae1c8f4a429c43502758a4f5e8

Reaktionsgleichung

CCOC(=O)/C=C(/C)N
β-aminocrotonic acid ethyl ester
O=Cc1cccc(F)c1
3-fluorobenzaldehyde
CCOC(=O)CC(=O)C(=O)OCC
oxalacetic acid diethyl ester
→
CCOC(=O)C1=C(C(=O)OCC)C(c2cccc(F)c2)C(C(=O)OCC)=C(C)N1
2-Methyl-4-(3'-fluoropheny)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester

Edukte

CCOC(=O)/C=C(/C)N
β-aminocrotonic acid ethyl ester
O=Cc1cccc(F)c1
3-fluorobenzaldehyde
CCOC(=O)CC(=O)C(=O)OCC
oxalacetic acid diethyl ester

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigethe mixture is evaporated in vacuo
  2. 2
    Sonstigea light yellow oil is obtained

Vorschrift

6.2 g of 3-fluorobenzaldehyde, 6.5 g of β-aminocrotonic acid ethyl ester and 9.5 g of oxalacetic acid diethyl ester in 40 ccs of ethanol are heated to the boil overnight, the mixture is evaporated in vacuo and a light yellow oil is obtained.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US03943140uspto-grants-1976_03