Reaktion #354685

Reaktionsgleichung

p-toluenesulfonylpiperazine

1-bromo-2-chloroethane

triethylamine

→

N-β-chloroethyl-N'-p-toluenesulfonylpiperazine

Ausbeute 80.6%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter refluxing for 72 hours a reaction mixture
2. 2
   Filtrationthe solution was filtered
3. 3
   Sonstigewhite needle crystal were obtained from the filtrate

Vorschrift

After refluxing for 72 hours a reaction mixture consisting of 60 g (0.25 mol) of p-toluenesulfonylpiperazine (III), 41 ml (0.5 mol) of 1-bromo-2-chloroethane and 35 ml (0.25 mol) of triethylamine in 1 liter of benzene, the solution was filtered and white needle crystal were obtained from the filtrate. N-β-chloroethyl-N'-p-toluenesulfonylpiperazine 61 g (yield: 79%) was obtained.

Quelle